UHRF1BP1L

Across TCGA patient cohorts, UHRF1BP1L mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UHRF1BP1L-associated genes across cancer lineages are p53, p62 Lck ligand, and c-Myc. Each is linked with UHRF1BP1L in more than 2 cancer types. Because this analysis shows association rather than direction, both UHRF1BP1L-to-partner and partner-to-UHRF1BP1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by UHRF1BP1L-low versus UHRF1BP1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UHRF1BP1L→partner) and Y-score (partner→UHRF1BP1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p53 →	-0.255	-2.169	.025	.003	3	3
UCEC	p62 Lck ligand →	+0.253	+1.241	.008	.015	3	3
BRCA	c-Myc →	+0.359	+2.812	.020	.037	3	2
COAD	eEF2 →	+0.379	+2.841	.003	.033	3	2
COAD	INPP4B →	-0.556	-3.321	<.001	.009	3	2
UCEC	JNK2 →	+0.207	+1.432	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p53 by UHRF1BP1L expression — UCEC

Explore this box plot interactively →