UHRF1BP1L

Across TCGA pan-cancer cohorts, UHRF1BP1L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of UHRF1BP1L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UHRF1BP1L RNA is repressed in tumor relative to normal tissue. In most cancer types UHRF1BP1L is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where UHRF1BP1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UHRF1BP1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.533	<.001	10	view →
THCA	All	II,III,IV	−0.623	<.001	8	view →
HNSC	All	II,III,IV	+0.536	<.001	8	view →
BRCA	All	III,IV	+0.485	<.001	8	view →
KIRC	All	All	+0.251	.002	7	view →
LUSC	All	All	−0.252	.003	4	view →
LUAD	Female	II,III,IV	−0.608	.001	3	view →
READ	Female	All	−0.838	.032	2	view →
LIHC	Male	All	+0.523	.002	2	view →
PAAD	Female	All	−0.430	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

UHRF1BP1L–COAD

Open the COAD breakdown →