UHRF1BP1

Across TCGA patient cohorts, UHRF1BP1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UHRF1BP1-associated genes across cancer lineages are PKC-delta_pS664, INPP4B, and p38-MAPK_pT180_Y182. Each is linked with UHRF1BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UHRF1BP1-to-partner and partner-to-UHRF1BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by UHRF1BP1-low versus UHRF1BP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UHRF1BP1→partner) and Y-score (partner→UHRF1BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-delta_pS664 →	-0.147	-2.991	.034	.036	3	2
UCEC	INPP4B →	-0.198	-2.584	.046	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.303	-1.678	.027	.021	3	2
UCEC	P-Cadherin →	-0.109	-2.222	.013	.009	3	2
UCEC	Rictor_pT1135 →	-0.083	-1.765	.008	.013	3	2
UCEC	STAT3_pY705 →	-0.358	-1.864	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PKC-delta_pS664 by UHRF1BP1 expression — COAD

Explore this box plot interactively →