UHRF1

Across TCGA patient cohorts, UHRF1 mutation is significantly associated with the RNA expression of many other genes, with 2,675 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UHRF1-associated genes across cancer lineages are PPP2CB, KCTD9, and KLHL18. Each is linked with UHRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UHRF1-to-partner and partner-to-UHRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2CB grouped by UHRF1-low versus UHRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UHRF1→partner) and Y-score (partner→UHRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2CB →	+0.496	+1.934	<.001	.002	3	3
COAD	KCTD9 →	+0.749	+3.223	.003	.009	3	3
UCEC	KLHL18 →	+0.450	+2.129	<.001	.002	3	3
UCEC	EXOSC9 →	+0.412	+2.526	.001	.001	3	3
UCEC	HAUS2 →	+0.557	+2.513	<.001	<.001	3	3
UCEC	CENPE →	+0.485	+2.374	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,675 associations by consensus.

PPP2CB by UHRF1 expression — UCEC

Explore this box plot interactively →