UHRF1

Across TCGA pan-cancer cohorts, UHRF1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UHRF1 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher UHRF1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UHRF1 expression acts as an unfavorable survival marker, although some lineages such as UCS and GBM show a favorable association.

ACC, MESO, and KIRP are the cancer types where UHRF1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.315	0.876	<.001	163	view →
MESO	OS	Median	All	0.355	0.723	<.001	147	view →
KIRP	OS	Tertile	All	0.560	0.826	<.001	111	view →
KICH	OS	Median	III,IV	0.363	0.957	<.001	98	view →
KIRC	DFS	Tertile	All	0.526	0.692	<.001	93	view →
LIHC	DFS	Tertile	All	0.416	0.638	<.001	75	view →
PAAD	DFS	Median	All	0.171	0.414	<.001	58	view →
SKCM	DFS	Median	All	0.519	0.753	<.001	55	view →
LUAD	OS	Tertile	All	0.597	0.758	<.001	51	view →
UVM	DFS	Median	All	0.317	0.679	<.001	50	view →
SARC	DFS	Median	All	0.407	0.621	<.001	42	view →
UCS	OS	Median	II,III,IV	0.653	0.353	.016	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UHRF1–ACC (OS)

Open the ACC breakdown →