UHRF1

Across TCGA patient cohorts, UHRF1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UHRF1-associated genes across cancer lineages are GAPDH, MEK1, and mTOR_pS2448. Each is linked with UHRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UHRF1-to-partner and partner-to-UHRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by UHRF1-low versus UHRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UHRF1→partner) and Y-score (partner→UHRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.568	+3.459	.005	.005	3	2
UCEC	MEK1 →	+0.567	+3.247	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.203	-2.787	<.001	.003	3	2
UCEC	PEA-15_pS116 →	+0.387	+3.169	.003	.018	3	2
UCEC	ATM →	-0.772	-3.247	<.001	<.001	2	3
UCEC	4E-BP1_pT37_T46 →	-0.319	-1.678	.026	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

GAPDH by UHRF1 expression — UCEC

Explore this box plot interactively →