UGT8

Across TCGA pan-cancer cohorts, UGT8 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated UGT8 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher UGT8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UGT8 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, UCEC, and OV are the cancer types where UGT8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.082	0.708	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.936	0.433	.011	26	view →
OV	OS	Median	All	0.244	0.690	.006	18	view →
CESC	DFS	Median	III,IV	0.053	0.729	<.001	18	view →
THYM	DFS	Median	All	0.075	0.885	<.001	12	view →
BRCA	OS	Median	III,IV	0.198	0.833	<.001	12	view →
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	12	view →
LIHC	OS	Median	All	0.031	0.777	<.001	12	view →
SARC	DFS	Median	All	0.181	0.614	.005	9	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	6	view →
SKCM	OS	Median	All	0.405	0.786	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

UGT8–SCLC (OS)

Open the SCLC breakdown →