UGT8

Across TCGA pan-cancer cohorts, UGT8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UGT8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where UGT8 RNA is repressed in tumor relative to normal tissue. In most cancer types UGT8 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and STAD are the cancer types where UGT8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UGT8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.811	<.001	12	view →
THCA	Male	IV	−2.540	<.001	11	view →
STAD	Male	All	+1.739	<.001	8	view →
LUAD	Male	All	+1.606	<.001	8	view →
KIRP	Male	III,IV	−2.012	<.001	7	view →
BRCA	Female	II,III,IV	−1.235	<.001	6	view →
HNSC	Male	IV	+1.839	.003	4	view →
LUSC	Male	All	+1.547	<.001	4	view →
CHOL	All	All	+2.188	.002	2	view →
PAAD	All	All	+1.447	.040	2	view →
UCEC	All	All	+1.133	.014	2	view →
PRAD	All	All	−0.228	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UGT8–KIRC

Open the KIRC breakdown →