UGT8

Across TCGA pan-cancer cohorts, UGT8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UGT8 data layer compared with 24 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher UGT8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UGT8 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

GBM, LSCC, and PDAC are the cancer types where UGT8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.252	0.610	.006	8	view →
LSCC	OS	Median	II,III,IV	0.921	1.000	.020	3	view →
PDAC	DFS	Quartile	All	0.645	0.836	.020	2	view →
HNSC	DFS	Median	III,IV	0.906	0.981	.038	1	view →
LUAD	OS	Median	All	1.000	0.922	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UGT8–GBM (OS)

Open the GBM breakdown →