UGT8

Across TCGA patient cohorts, UGT8 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT8-associated genes across cancer lineages are PCNA, SF2, and Beclin. Each is linked with UGT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT8-to-partner and partner-to-UGT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by UGT8-low versus UGT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT8→partner) and Y-score (partner→UGT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.184	+1.523	.007	.008	3	2
LUSC	SF2 →	+0.154	+2.834	.018	.035	3	1
LUSC	Beclin →	+0.203	+2.834	.007	.035	3	1
LUSC	cIAP →	+0.253	+2.816	<.001	.036	3	1
UCEC	A-Raf_pS299 →	-0.102	-1.700	.007	.042	3	1
UCEC	ERK2 →	+0.162	+1.584	.008	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PCNA by UGT8 expression — UCEC

Explore this box plot interactively →