UGT8

Across TCGA cell cohorts, UGT8 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGT8-associated genes across cancer lineages are MYF6, OR1L6, and IQCF6. Each is linked with UGT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT8-to-partner and partner-to-UGT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by UGT8-low versus UGT8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT8→partner) and Y-score (partner→UGT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYF6 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR1L6 →	+0.027	+5.022	<.001	.002	3	1
LARGE_INTESTINE	IQCF6 →	+0.322	+4.467	<.001	.004	3	1
LARGE_INTESTINE	OR12D2 →	+0.103	+4.467	<.001	.004	3	1
BLOOD_Lymphoma	OR6B1 →	+0.017	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MYF6 by UGT8 expression — LARGE_INTESTINE

Explore this box plot interactively →