UGT3A2

Across TCGA patient cohorts, UGT3A2 mutation is significantly associated with the RNA expression of many other genes, with 3,440 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT3A2-associated genes across cancer lineages are TYMSOS, CKS2, and ACP1. Each is linked with UGT3A2 in more than 3 cancer types. Because this analysis shows association rather than direction, both UGT3A2-to-partner and partner-to-UGT3A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMSOS grouped by UGT3A2-low versus UGT3A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT3A2→partner) and Y-score (partner→UGT3A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMSOS →	+0.793	+4.010	<.001	<.001	3	4
UCEC	CKS2 →	+0.726	+3.087	<.001	<.001	3	4
LUSC	ACP1 →	+0.428	+3.232	.003	.009	3	4
SKCM	MASTL →	+0.446	+1.790	.001	<.001	3	4
LUAD	MTPAP →	+0.455	+3.404	.002	.004	3	3
READ	RN7SL66P →	+0.120	+4.341	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,440 associations by consensus.

TYMSOS by UGT3A2 expression — UCEC

Explore this box plot interactively →