UGT2A3

Across TCGA pan-cancer cohorts, UGT2A3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UGT2A3 data layer compared with 17 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher UGT2A3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UGT2A3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

BLCA, SKCM, and ACC are the cancer types where UGT2A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.147	0.627	<.001	27	view →
SKCM	OS	Median	All	0.978	0.860	.005	19	view →
ACC	OS	Median	All	0.245	0.809	<.001	15	view →
UCEC	DFS	Median	All	0.967	0.829	.033	14	view →
BRCA	OS	Median	All	0.928	0.924	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UGT2A3–BLCA (DFS)

Open the BLCA breakdown →