UGT2A3

Across TCGA patient cohorts, UGT2A3 mutation is significantly associated with the RNA expression of many other genes, with 3,622 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2A3-associated genes across cancer lineages are MIR6893, DDIT3, and IP6K1. Each is linked with UGT2A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT2A3-to-partner and partner-to-UGT2A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6893 grouped by UGT2A3-low versus UGT2A3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2A3→partner) and Y-score (partner→UGT2A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR6893 →	+0.368	+3.417	<.001	.001	3	3
UCEC	DDIT3 →	+0.466	+3.480	.007	.002	3	3
UCEC	IP6K1 →	+0.386	+3.491	.001	.002	3	3
UCEC	GEMIN2 →	+0.490	+2.010	.001	.001	3	3
UCEC	FAF1 →	+0.360	+3.523	<.001	<.001	3	3
UCEC	DDX51 →	+0.285	+2.533	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,622 associations by consensus.

MIR6893 by UGT2A3 expression — LUSC

Explore this box plot interactively →