UGT2A3

Across TCGA patient cohorts, UGT2A3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2A3-associated genes across cancer lineages are VHL, XBP1, and FoxM1. Each is linked with UGT2A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT2A3-to-partner and partner-to-UGT2A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by UGT2A3-low versus UGT2A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2A3→partner) and Y-score (partner→UGT2A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.672	-2.222	.009	.010	3	2
SKCM	XBP1 →	-0.206	-3.584	.011	.002	3	2
UCEC	FoxM1 →	+0.196	+2.087	.048	.005	3	2
UCEC	FOXO3a_pS318_S321 →	-0.137	-1.797	.004	.025	3	2
UCEC	Ku80 →	+0.252	+1.691	.005	.014	3	2
UCEC	PCNA →	+0.260	+2.087	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

VHL by UGT2A3 expression — UCEC

Explore this box plot interactively →