UGT2A3

Across TCGA cell cohorts, UGT2A3 RNA expression is significantly associated with the go_rna of many other GO terms, with 708 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible UGT2A3-associated GO terms across cancer lineages are Trans-synaptic signaling by BDNF, modulating synaptic transmission, Trans-synaptic signaling by BDNF, and Renal D-glucose absorption. Each is linked with UGT2A3 in more than 4 cancer types. Because this analysis shows association rather than direction, both UGT2A3-to-partner and partner-to-UGT2A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trans-synaptic signaling by BDNF, modulating synaptic transmission grouped by UGT2A3-low versus UGT2A3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2A3→partner) and Y-score (partner→UGT2A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Trans-synaptic signaling by BDNF, modulating synaptic transmission →	-1.143	-0.020	.001	.004	3	5
LUNG_NSCLC_LUSC	Trans-synaptic signaling by BDNF →	-1.143	-0.020	.001	.004	3	5
LIVER	Renal D-glucose absorption →	+1.755	+2.874	<.001	<.001	3	5
KIDNEY	Mitochondrion to lysosome vesicle-mediated transport →	-0.203	-1.973	<.001	<.001	3	4
KIDNEY	Mitochondrion-derived vesicle mediated transport →	-0.203	-1.973	<.001	<.001	3	4
LIVER	Primary alcohol metabolic process →	+0.155	+3.104	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 708 associations by consensus.

Trans-synaptic signaling by BDNF, modulating synaptic transmission by UGT2A3 expression — LUNG_NSCLC_LUSC

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