UGT2A1

Across TCGA patient cohorts, UGT2A1 mutation is significantly associated with the RNA expression of many other genes, with 3,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2A1-associated genes across cancer lineages are MTND6P8, RNU6-937P, and OR4D9. Each is linked with UGT2A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both UGT2A1-to-partner and partner-to-UGT2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND6P8 grouped by UGT2A1-low versus UGT2A1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2A1→partner) and Y-score (partner→UGT2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MTND6P8 →	+0.123	+4.424	<.001	.008	3	4
HNSC	RNU6-937P →	+0.688	+4.321	<.001	.003	3	3
LUSC	OR4D9 →	+0.120	+4.424	<.001	.004	3	3
UCEC	MRPL22 →	+0.253	+2.650	.001	<.001	3	3
LUAD	FOXRED1 →	+0.564	+2.632	<.001	.005	3	3
UCEC	CIDECP1 →	+0.348	+2.477	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,712 associations by consensus.

MTND6P8 by UGT2A1 expression — HNSC

Explore this box plot interactively →