UGGT1

Across TCGA pan-cancer cohorts, UGGT1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UGGT1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UGGT1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UGGT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where UGGT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.302	0.825	.001	18	view →
CCRCC	OS	Tertile	All	0.569	1.000	.011	8	view →
GBM	DFS	Tertile	All	0.652	0.871	.003	8	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.319	.024	4	view →
PDAC	OS	Median	All	0.518	0.312	.021	3	view →
HNSC	DFS	Tertile	IV	0.908	1.000	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UGGT1–LUAD (OS)

Open the LUAD breakdown →