UGGT1

Across TCGA pan-cancer cohorts, UGGT1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of UGGT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UGGT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UGGT1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where UGGT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UGGT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.048	<.001	12	view →
BLCA	Female	All	+1.136	<.001	11	view →
COAD	Male	All	+0.660	<.001	10	view →
KIRP	All	II,III,IV	+0.653	.001	10	view →
LIHC	Male	II,III,IV	+1.645	<.001	9	view →
STAD	Male	II,III,IV	+1.337	<.001	9	view →
LUAD	Male	II,III,IV	+1.041	<.001	9	view →
KIRC	All	All	+0.343	<.001	9	view →
LUSC	Female	All	+1.101	<.001	8	view →
UCEC	All	All	+0.799	<.001	6	view →
BRCA	All	II,III,IV	+0.536	<.001	6	view →
THCA	All	All	−0.341	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

UGGT1–HNSC

Open the HNSC breakdown →