UGGT1

Across TCGA patient cohorts, UGGT1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGGT1-associated genes across cancer lineages are ATM, A-Raf_pS299, and ERK2. Each is linked with UGGT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGGT1-to-partner and partner-to-UGGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UGGT1-low versus UGGT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGGT1→partner) and Y-score (partner→UGGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.359	-1.064	.009	.048	3	3
UCEC	A-Raf_pS299 →	-0.105	-1.807	.004	.024	3	2
UCEC	ERK2 →	+0.170	+1.514	.003	.014	3	2
UCEC	Gab2 →	+0.258	+1.700	.018	.042	3	2
UCEC	p53 →	-0.286	-2.459	.015	.018	3	2
UCEC	S6_pS240_S244 →	+0.255	+2.000	.040	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by UGGT1 expression — UCEC

Explore this box plot interactively →