UGGT1

Across TCGA cell cohorts, UGGT1 mutation is significantly associated with the RNA expression of many other genes, with 528 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGGT1-associated genes across cancer lineages are SGCB, CPLX4, and FAM166B. Each is linked with UGGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGGT1-to-partner and partner-to-UGGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGCB grouped by UGGT1-low versus UGGT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGGT1→partner) and Y-score (partner→UGGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGCB →	+0.875	+3.212	.009	.006	3	2
LARGE_INTESTINE	CPLX4 →	+0.023	+2.667	<.001	.002	3	2
LARGE_INTESTINE	FAM166B →	+0.496	+3.212	<.001	.006	3	2
BLOOD_Leukemia	PRSS55 →	+0.045	+3.897	.001	.001	3	2
LUNG_NSCLC_LUAD	VSTM2B →	+0.193	+4.212	<.001	.007	3	2
OVARY	SPANXN1 →	+0.036	+4.029	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 528 associations by consensus.

SGCB by UGGT1 expression — LARGE_INTESTINE

Explore this box plot interactively →