UGDH

Across TCGA pan-cancer cohorts, UGDH mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UGDH data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UGDH mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UGDH expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, GBM, and HNSC are the cancer types where UGDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.623	1.000	.001	38	view →
GBM	DFS	Median	All	0.249	0.481	.001	16	view →
HNSC	OS	Median	II,III,IV	0.618	0.823	.009	10	view →
LUAD	OS	Median	II,III,IV	0.449	0.893	.023	2	view →
UCEC	DFS	Quartile	All	0.969	0.808	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UGDH–CCRCC (OS)

Open the CCRCC breakdown →