UGDH

Across TCGA patient cohorts, UGDH mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGDH-associated genes across cancer lineages are ASNS, EGFR_pY1068, and eIF4G. Each is linked with UGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both UGDH-to-partner and partner-to-UGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by UGDH-low versus UGDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGDH→partner) and Y-score (partner→UGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.510	+2.807	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.205	-1.807	.047	.027	3	1
UCEC	eIF4G →	+0.307	+3.169	.016	.018	3	1
UCEC	INPP4B →	-0.293	-1.874	.028	.049	3	1
UCEC	mTOR_pS2448 →	-0.159	-3.308	.009	.009	3	1
UCEC	p62 Lck ligand →	+0.373	+2.469	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ASNS by UGDH expression — UCEC

Explore this box plot interactively →