UGDH

Across TCGA cell cohorts, UGDH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,515 significant associations in total. BONE shows the largest number of these associations.

The most reproducible UGDH-associated GO terms across cancer lineages are Positive regulation of ER to Golgi vesicle-mediated transport, Response to hepatocyte growth factor, and Cellular response to hepatocyte growth factor stimulus. Each is linked with UGDH in more than 8 cancer types. Because this analysis shows association rather than direction, both UGDH-to-partner and partner-to-UGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ER to Golgi vesicle-mediated transport grouped by UGDH-low versus UGDH-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UGDH→partner) and Y-score (partner→UGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of ER to Golgi vesicle-mediated transport →	+0.139	+1.532	<.001	<.001	3	9
BONE	Response to hepatocyte growth factor →	+0.199	+1.149	<.001	.004	3	9
LUNG_SCLC	Cellular response to hepatocyte growth factor stimulus →	+0.152	+1.799	.002	<.001	3	9
BREAST	Nucleotide-sugar biosynthetic process →	+0.095	+1.746	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Nucleotide-sugar metabolic process →	+0.090	+1.439	<.001	<.001	3	9
BONE	Regulation of muscle adaptation →	+0.084	+1.022	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,515 associations by consensus.

Positive regulation of ER to Golgi vesicle-mediated transport by UGDH expression — BONE

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