UGDH

Across TCGA cell cohorts, UGDH mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UGDH-associated genes across cancer lineages are C6orf118, SSMEM1, and PRAMEF20. Each is linked with UGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both UGDH-to-partner and partner-to-UGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by UGDH-low versus UGDH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGDH→partner) and Y-score (partner→UGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ADAM7 →	+0.005	+3.930	<.001	.003	3	1
BLOOD_Leukemia	PPP1R2C →	+0.307	+5.539	<.001	.003	3	1
BLOOD_Leukemia	CST8 →	+0.062	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C6orf118 by UGDH expression — LARGE_INTESTINE

Explore this box plot interactively →