UGCG

Across TCGA cell cohorts, UGCG mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGCG-associated genes across cancer lineages are OR1L4, AVP, and IL31. Each is linked with UGCG in more than 1 cancer types. Because this analysis shows association rather than direction, both UGCG-to-partner and partner-to-UGCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L4 grouped by UGCG-low versus UGCG-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGCG→partner) and Y-score (partner→UGCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR1L4 →	+0.080	+5.087	<.001	.004	3	1
CNS	AVP →	+0.048	+4.981	.001	.008	3	1
CNS	IL31 →	+0.031	+4.981	<.001	.008	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	FMR1NB →	+0.210	+3.453	<.001	.009	3	1
LARGE_INTESTINE	PTH2R →	+1.125	+3.453	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR1L4 by UGCG expression — URINARY_TRACT

Explore this box plot interactively →