UGCG

Across TCGA pan-cancer cohorts, UGCG RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of UGCG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where UGCG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UGCG is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

KIRP, BLCA, and BRCA are the cancer types where UGCG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UGCG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	+1.519	<.001	9	view →
BLCA	Female	III,IV	−1.551	<.001	6	view →
BRCA	All	III,IV	+1.063	<.001	6	view →
KIRC	All	All	+0.662	<.001	6	view →
THCA	All	III,IV	+0.534	.004	6	view →
LIHC	Female	All	+0.799	<.001	4	view →
CHOL	All	All	+1.220	.001	3	view →
COAD	All	All	−0.400	.007	3	view →
READ	Female	All	−0.645	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

UGCG–KIRP

Open the KIRP breakdown →