UEVLD

Across TCGA patient cohorts, UEVLD mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UEVLD-associated genes across cancer lineages are PCNA, FASN, and eEF2. Each is linked with UEVLD in more than 2 cancer types. Because this analysis shows association rather than direction, both UEVLD-to-partner and partner-to-UEVLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by UEVLD-low versus UEVLD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UEVLD→partner) and Y-score (partner→UEVLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.277	+3.000	.001	.001	3	3
UCEC	FASN →	+0.326	+1.807	.045	.027	3	2
UCEC	eEF2 →	+0.385	+1.807	.009	.027	3	1
UCEC	EGFR_pY1068 →	-0.301	-2.700	.003	.006	3	1
UCEC	HER2_pY1248 →	-0.218	-3.000	.048	.001	3	1
UCEC	JNK2 →	+0.218	+1.807	.007	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PCNA by UEVLD expression — UCEC

Explore this box plot interactively →