UCP3

Across TCGA patient cohorts, UCP3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCP3-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and JNK2. Each is linked with UCP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCP3-to-partner and partner-to-UCP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by UCP3-low versus UCP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCP3→partner) and Y-score (partner→UCP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.242	+2.999	.007	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.189	-3.000	.016	.036	3	1
UCEC	JNK2 →	+0.305	+3.009	<.001	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.210	+1.887	.029	.031	3	1
UCEC	Myosin-IIa →	+0.323	+2.818	<.001	.035	3	1
UCEC	Akt_pT308 →	+0.711	+3.169	.015	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ERK2 by UCP3 expression — UCEC

Explore this box plot interactively →