UCP3

Across TCGA pan-cancer cohorts, UCP3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UCP3 data layer compared with 4 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher UCP3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated UCP3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and PAAD show a favorable association.

BLCA, ACC, and PAAD are the cancer types where UCP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	All	0.700	0.521	.002	87	view →
ACC	DFS	Quartile	All	0.341	0.698	.003	73	view →
PAAD	DFS	Quartile	II,III,IV	0.380	0.247	.008	48	view →
LGG	DFS	Median	All	0.640	0.828	<.001	46	view →
UCS	DFS	Quartile	II,III,IV	0.551	0.190	.004	36	view →
BRCA	OS	Median	III,IV	0.902	0.761	<.001	35	view →
SKCM	OS	Quartile	All	0.474	0.299	.009	31	view →
SCLC	DFS	Tertile	All	0.537	0.249	.005	28	view →
PRAD	DFS	Median	All	0.833	0.931	<.001	26	view →
UCEC	DFS	Median	IV	0.697	0.294	.013	24	view →
LIHC	OS	Tertile	All	0.653	0.808	.007	21	view →
KIRC	DFS	Tertile	All	0.489	0.653	.006	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UCP3–BLCA (OS)

Open the BLCA breakdown →