UCP3

Across TCGA cell cohorts, UCP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,972 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UCP3-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Post-transcriptional gene silencing, and Regulation of DNA-templated transcription initiation. Each is linked with UCP3 in more than 15 cancer types. Because this analysis shows association rather than direction, both UCP3-to-partner and partner-to-UCP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by UCP3-low versus UCP3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UCP3→partner) and Y-score (partner→UCP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of mRNA splicing, via spliceosome →	+0.092	+0.603	<.001	<.001	3	16
LUNG_SCLC	Post-transcriptional gene silencing →	+0.086	+0.880	<.001	.001	3	15
OESOPHAGUS	Regulation of DNA-templated transcription initiation →	+0.079	+0.790	<.001	<.001	3	15
OESOPHAGUS	Spliceosomal complex assembly →	+0.098	+0.561	.004	.006	3	15
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.189	+0.660	<.001	<.001	3	15
BONE	Regulation of alternative mRNA splicing, via spliceosome →	+0.119	+0.935	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,972 associations by consensus.

Regulation of mRNA splicing, via spliceosome by UCP3 expression — BLOOD_Lymphoma

Explore this box plot interactively →