UCHL1

Across TCGA cell cohorts, UCHL1 mutation is significantly associated with the mutation status of many other genes, with 2,408 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UCHL1-associated genes across cancer lineages are NEBL, TULP3, and ADCY2. Each is linked with UCHL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCHL1-to-partner and partner-to-UCHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEBL grouped by UCHL1-low versus UCHL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCHL1→partner) and Y-score (partner→UCHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEBL →	+3.329	+3.799	.005	.005	1	1
LARGE_INTESTINE	TULP3 →	+3.744	+4.044	.003	.003	1	1
LARGE_INTESTINE	ADCY2 →	+2.043	+3.693	.009	.009	1	1
LARGE_INTESTINE	ZCWPW1 →	+4.159	+5.215	<.001	<.001	1	1
LARGE_INTESTINE	CDH17 →	+3.744	+5.000	<.001	<.001	1	1
LARGE_INTESTINE	THOC1 →	+3.422	+4.807	<.001	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,408 associations by consensus.

NEBL by UCHL1 expression — LARGE_INTESTINE

Explore this box plot interactively →