UBXN2A

Across TCGA pan-cancer cohorts, UBXN2A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UBXN2A data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UBXN2A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UBXN2A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where UBXN2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.972	0.736	<.001	62	view →
HNSC	DFS	Quartile	III,IV	0.956	0.595	.002	53	view →
PDAC	DFS	Median	All	0.637	0.884	.010	7	view →
LUAD	OS	Quartile	II,III,IV	0.715	0.243	.045	2	view →
LSCC	OS	Quartile	All	0.938	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UBXN2A–CCRCC (OS)

Open the CCRCC breakdown →