UBXN2A

Across TCGA pan-cancer cohorts, UBXN2A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of UBXN2A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBXN2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBXN2A is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where UBXN2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBXN2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.655	<.001	11	view →
LIHC	All	II,III,IV	+0.640	<.001	9	view →
KICH	Female	All	−1.235	<.001	8	view →
LUSC	Female	All	+0.791	<.001	6	view →
BRCA	All	III,IV	−0.581	<.001	6	view →
CHOL	Male	All	+1.523	<.001	5	view →
LUAD	Male	All	+0.323	.009	4	view →
THCA	All	All	−0.187	.016	3	view →
ESCA	All	All	+0.665	.006	2	view →
BLCA	All	All	+0.292	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

UBXN2A–HNSC

Open the HNSC breakdown →