UBXN10

Across TCGA patient cohorts, UBXN10 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBXN10-associated genes across cancer lineages are eIF4E, MEK1, and PDCD4. Each is linked with UBXN10 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBXN10-to-partner and partner-to-UBXN10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by UBXN10-low versus UBXN10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBXN10→partner) and Y-score (partner→UBXN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.156	+2.115	.039	.017	3	2
UCEC	MEK1 →	+0.408	+2.662	.001	<.001	3	2
UCEC	PDCD4 →	-0.510	-2.105	.002	.017	3	2
UCEC	VHL →	-0.876	-1.584	<.001	.034	3	2
UCEC	ASNS →	+0.293	+1.700	.024	.042	3	2
UCEC	ATM →	-0.505	-3.308	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by UBXN10 expression — UCEC

Explore this box plot interactively →