UBXN1

Across TCGA pan-cancer cohorts, UBXN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBXN1 data layer compared with 29 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBXN1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UBXN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, COAD, and UCEC are the cancer types where UBXN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.814	0.634	.018	14	view →
COAD	DFS	Median	III,IV	0.832	1.000	.029	6	view →
UCEC	OS	Quartile	All	0.898	1.000	.033	2	view →
CCRCC	DFS	Median	II,III,IV	0.776	0.451	.008	2	view →
LSCC	DFS	Tertile	III,IV	0.827	1.000	.043	2	view →
PDAC	DFS	Tertile	III,IV	1.000	0.761	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBXN1–HNSC (OS)

Open the HNSC breakdown →