UBXN1

Across TCGA pan-cancer cohorts, UBXN1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UBXN1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where UBXN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBXN1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

LIHC, HNSC, and THCA are the cancer types where UBXN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBXN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.224	<.001	9	view →
HNSC	Male	III,IV	+0.564	<.001	8	view →
THCA	Male	All	+0.359	<.001	8	view →
KIRC	All	All	+0.231	.004	6	view →
CHOL	Female	All	+2.266	<.001	5	view →
KICH	All	All	−0.560	<.001	5	view →
BRCA	Female	II,III,IV	−0.424	<.001	4	view →
KIRP	All	IV	+0.797	.031	2	view →
UCEC	All	III,IV	−0.396	.049	2	view →
STAD	Male	II,III,IV	+0.392	.005	2	view →
COAD	All	II,III,IV	+0.186	.017	2	view →
ESCA	All	All	+0.502	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UBXN1–LIHC

Open the LIHC breakdown →