UBXN1

Across TCGA patient cohorts, UBXN1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBXN1-associated genes across cancer lineages are GAPDH, JNK2, and MSH2. Each is linked with UBXN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBXN1-to-partner and partner-to-UBXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by UBXN1-low versus UBXN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBXN1→partner) and Y-score (partner→UBXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.576	+2.321	.032	.035	3	1
UCEC	JNK2 →	+0.291	+2.321	.003	.035	3	1
UCEC	MSH2 →	-0.368	-2.321	.001	.035	3	1
UCEC	p70-S6K_pT389 →	-0.214	-2.321	.025	.035	3	1
UCEC	AMPK_pT172 →	+0.477	+3.472	.020	.002	3	1
UCEC	ATM →	-0.794	-2.986	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GAPDH by UBXN1 expression — UCEC

Explore this box plot interactively →