UBXN1

Across TCGA cell cohorts, UBXN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,220 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible UBXN1-associated GO terms across cancer lineages are Regulation of protein K48-linked deubiquitination, Response to mitochondrial depolarisation, and Transcription pausing by RNA polymerase II. Each is linked with UBXN1 in more than 16 cancer types. Because this analysis shows association rather than direction, both UBXN1-to-partner and partner-to-UBXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K48-linked deubiquitination grouped by UBXN1-low versus UBXN1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UBXN1→partner) and Y-score (partner→UBXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of protein K48-linked deubiquitination →	+0.121	+1.064	.001	<.001	3	17
BLOOD_Lymphoma	Response to mitochondrial depolarisation →	+0.081	+0.696	<.001	<.001	3	15
BLOOD_Lymphoma	Transcription pausing by RNA polymerase II →	+0.135	+0.766	<.001	<.001	3	10
LARGE_INTESTINE	mRNA cis splicing, via spliceosome →	+0.091	+0.726	<.001	<.001	3	10
LARGE_INTESTINE	Prolactin signaling pathway →	+0.159	+0.494	.009	.003	3	9
OVARY	Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.117	+0.460	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,220 associations by consensus.

Regulation of protein K48-linked deubiquitination by UBXN1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →