UBTFL1

Across TCGA patient cohorts, UBTFL1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBTFL1-associated genes across cancer lineages are JNK_pT183_Y185, 14-3-3_epsilon, and EGFR. Each is linked with UBTFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBTFL1-to-partner and partner-to-UBTFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by UBTFL1-low versus UBTFL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBTFL1→partner) and Y-score (partner→UBTFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.227	-2.308	.007	.036	3	2
UCEC	14-3-3_epsilon →	+0.122	+2.321	.013	.035	3	2
UCEC	EGFR →	-0.240	-2.321	.002	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.124	-2.990	.047	.036	3	1
UCEC	p62 Lck ligand →	+0.397	+3.009	.015	.019	3	1
UCEC	PDCD4 →	-0.800	-3.160	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

JNK_pT183_Y185 by UBTFL1 expression — UCEC

Explore this box plot interactively →