UBTFL1

Across TCGA pan-cancer cohorts, UBTFL1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated UBTFL1 data layer compared with 4 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher UBTFL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UBTFL1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and PAAD show a favorable association.

THCA, LIHC, and COAD are the cancer types where UBTFL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	IV	0.252	1.000	<.001	63	view →
LIHC	DFS	Tertile	II,III,IV	0.116	0.428	.001	63	view →
COAD	OS	Tertile	II,III,IV	0.027	0.860	<.001	36	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
ESCA	OS	Tertile	IV	0.743	0.290	.013	30	view →
LGG	OS	Tertile	All	0.538	0.818	<.001	30	view →
GBM	OS	Tertile	All	0.107	0.421	.010	27	view →
HNSC	OS	Tertile	All	0.158	0.380	.013	21	view →
STAD	OS	Tertile	III,IV	0.179	0.519	.044	18	view →
UCEC	OS	Tertile	All	0.836	0.928	.011	18	view →
SARC	OS	Tertile	All	0.610	0.842	.008	15	view →
PAAD	OS	Tertile	All	1.000	0.377	.040	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

UBTFL1–THCA (OS)

Open the THCA breakdown →