UBTF

Across TCGA patient cohorts, UBTF mutation is significantly associated with the RNA expression of many other genes, with 2,043 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBTF-associated genes across cancer lineages are RNU6-1194P, OR8B6P, and MIR3681. Each is linked with UBTF in more than 2 cancer types. Because this analysis shows association rather than direction, both UBTF-to-partner and partner-to-UBTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1194P grouped by UBTF-low versus UBTF-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBTF→partner) and Y-score (partner→UBTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1194P →	+0.146	+4.307	<.001	.005	3	3
KIRP	OR8B6P →	+0.146	+6.301	<.001	.001	3	3
KIRP	MIR3681 →	+0.868	+7.124	<.001	<.001	3	3
KIRP	PNPT1P2 →	+0.146	+5.060	<.001	.008	3	2
KIRP	TRIM60P16 →	+0.135	+5.770	<.001	.003	3	2
HNSC	LINC02146 →	+0.107	+4.936	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,043 associations by consensus.

RNU6-1194P by UBTF expression — BLCA

Explore this box plot interactively →