UBTD2

Across TCGA patient cohorts, UBTD2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBTD2-associated genes across cancer lineages are INPP4B, MEK1, and MSH2. Each is linked with UBTD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UBTD2-to-partner and partner-to-UBTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by UBTD2-low versus UBTD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBTD2→partner) and Y-score (partner→UBTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.319	-1.986	.028	.032	3	1
UCEC	MEK1 →	+0.341	+2.000	.039	.032	3	1
UCEC	MSH2 →	-0.266	-3.143	.010	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.496	-2.321	.014	.034	3	1
UCEC	p62 Lck ligand →	+0.298	+2.999	.042	.035	3	1
UCEC	PCNA →	+0.242	+3.169	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

INPP4B by UBTD2 expression — UCEC

Explore this box plot interactively →