UBR5-AS1

Across TCGA pan-cancer cohorts, UBR5-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated UBR5-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher UBR5-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UBR5-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

KIRC, LIHC, and BLCA are the cancer types where UBR5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.425	0.652	<.001	124	view →
LIHC	OS	Median	All	0.598	0.774	<.001	111	view →
BLCA	OS	Quartile	All	0.690	0.508	.001	88	view →
UVM	DFS	Tertile	III,IV	0.178	0.854	<.001	74	view →
KIRP	DFS	Tertile	III,IV	0.114	0.593	.001	64	view →
KICH	OS	Median	II,III,IV	0.737	1.000	.003	57	view →
ACC	DFS	Tertile	II,III,IV	0.357	0.745	.001	57	view →
SKCM	OS	Tertile	All	0.859	0.655	<.001	41	view →
ESCA	OS	Median	All	0.466	1.000	.016	11	view →
THCA	DFS	Tertile	II,III,IV	0.923	0.983	.013	10	view →
BRCA	OS	Median	All	0.540	0.629	.023	9	view →
HNSC	OS	Median	III,IV	0.575	0.768	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

UBR5-AS1–KIRC (DFS)

Open the KIRC breakdown →