UBR5-AS1

Across TCGA pan-cancer cohorts, UBR5-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of UBR5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UBR5-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types UBR5-AS1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where UBR5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UBR5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.398	<.001	10	view →
LIHC	Male	II,III,IV	+1.285	<.001	9	view →
THCA	Male	All	−0.505	<.001	8	view →
LUSC	Female	All	−0.549	<.001	7	view →
KICH	All	All	−0.725	<.001	5	view →
LUAD	Female	II,III,IV	−0.549	.001	5	view →
KIRC	All	All	−0.292	.001	5	view →
CHOL	All	All	+1.500	<.001	3	view →
STAD	All	II,III,IV	+0.657	.003	3	view →
ESCA	Male	All	+0.864	.002	2	view →
PRAD	All	All	+0.435	<.001	2	view →
UCEC	All	All	−0.425	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

UBR5-AS1–HNSC

Open the HNSC breakdown →