UBR3

Across TCGA pan-cancer cohorts, UBR3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated UBR3 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UBR3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UBR3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, MESO, and KICH are the cancer types where UBR3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.110	0.752	<.001	72	view →
MESO	OS	Median	IV	0.036	0.602	<.001	42	view →
KICH	DFS	Median	All	0.025	0.904	<.001	36	view →
UCEC	DFS	Median	All	0.950	0.616	.001	34	view →
OV	OS	Median	II,III,IV	0.511	0.844	<.001	12	view →
BRCA	OS	Median	III,IV	0.001	0.907	<.001	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LIHC	OS	Median	All	0.156	0.774	.005	6	view →
LUAD	OS	Median	All	0.250	0.788	.010	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

UBR3–HNSC (OS)

Open the HNSC breakdown →