UBR3

Across TCGA pan-cancer cohorts, UBR3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UBR3 data layer compared with 22 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UBR3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated UBR3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where UBR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	1.000	0.712	.001	38	view →
LUAD	DFS	Quartile	II,III,IV	0.665	0.375	.004	24	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	10	view →
GBM	DFS	Median	All	0.856	0.649	.009	9	view →
CCRCC	DFS	Quartile	II,III,IV	0.370	0.755	.005	6	view →
LSCC	DFS	Quartile	II,III,IV	0.923	1.000	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UBR3–UCEC (OS)

Open the UCEC breakdown →