UBR2

Across TCGA patient cohorts, UBR2 mutation is significantly associated with the RNA expression of many other genes, with 3,060 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBR2-associated genes across cancer lineages are OIP5, SFXN1, and RAN. Each is linked with UBR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both UBR2-to-partner and partner-to-UBR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by UBR2-low versus UBR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR2→partner) and Y-score (partner→UBR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.505	+2.153	.003	<.001	3	4
UCEC	SFXN1 →	+0.422	+1.632	<.001	<.001	3	4
SKCM	RAN →	+0.404	+3.459	.009	.005	3	3
OV	RNU6-1241P →	+0.380	+5.063	<.001	.008	3	3
HNSC	RNU6-33P →	+0.400	+3.041	.003	.001	3	3
CESC	PLA2G12AP2 →	+0.112	+5.164	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,060 associations by consensus.

OIP5 by UBR2 expression — UCEC

Explore this box plot interactively →