UBR1

Across TCGA patient cohorts, UBR1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UBR1-associated genes across cancer lineages are TFRC, eEF2, and PCNA. Each is linked with UBR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UBR1-to-partner and partner-to-UBR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by UBR1-low versus UBR1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UBR1→partner) and Y-score (partner→UBR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TFRC →	+0.616	+3.000	.033	.036	3	3
UCEC	eEF2 →	+0.211	+1.678	.034	.019	3	3
UCEC	PCNA →	+0.179	+2.321	.002	<.001	3	3
UCEC	Shc_pY317 →	-0.129	-1.440	.002	.020	3	3
SKCM	YAP_pS127 →	-0.364	-1.906	.011	.016	3	3
COAD	GSK3-a-b →	+0.201	+2.849	.016	.034	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

TFRC by UBR1 expression — LUAD

Explore this box plot interactively →