UBR1

Across TCGA pan-cancer cohorts, UBR1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated UBR1 data layer compared with 2 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher UBR1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated UBR1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, UVM, and ACC are the cancer types where UBR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.764	0.542	<.001	84	view →
UVM	DFS	Quartile	All	0.277	0.787	<.001	70	view →
ACC	DFS	Median	All	0.403	0.760	<.001	69	view →
LUSC	DFS	Median	III,IV	0.339	0.883	.002	40	view →
OV	OS	Tertile	All	0.772	0.876	.002	38	view →
CESC	DFS	Tertile	All	0.630	0.827	<.001	34	view →
HNSC	OS	Median	II,III,IV	0.613	0.804	.007	34	view →
SKCM	OS	Quartile	III,IV	0.427	0.234	.006	23	view →
KIRP	OS	Median	IV	0.045	0.523	.024	18	view →
PAAD	DFS	Median	All	0.220	0.470	.009	17	view →
BRCA	DFS	Tertile	All	0.505	0.662	.012	15	view →
LGG	OS	Quartile	All	0.714	0.908	.004	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

UBR1–KIRC (OS)

Open the KIRC breakdown →